Performance of contrast enhanced SSFP and T2-weighted imaging for determining myocardium at risk in a multi-vendor, multi-center setting- data from the MITOCARE and CHILL-MI trials
نویسندگان
چکیده
Background Myocardial salvage, as determined by cardiac magnetic resonance imaging (CMR), is increasingly used as an endpoint in clinical trials. In order to calculate myocardial salvage, the infarct size needs to be related to myocardium at risk (MaR). MaR has previously been assessed by both T2-weighted imaging and contrast enhanced SSFP (CESSFP). The aim of this study was to determine how T2-weighted triple inversion recovery imaging (T2w) and CE-SSFP perform in determining MaR in multi-vendor, multi-center clinical cardioprotection trials.
منابع مشابه
Multi-vendor, multicentre comparison of contrast-enhanced SSFP and T2-STIR CMR for determining myocardium at risk in ST-elevation myocardial infarction
AIMS Myocardial salvage, determined by cardiac magnetic resonance imaging (CMR), is used as end point in cardioprotection trials. To calculate myocardial salvage, infarct size is related to myocardium at risk (MaR), which can be assessed by T2-short tau inversion recovery (T2-STIR) and contrast-enhanced steady-state free precession magnetic resonance imaging (CE-SSFP). We aimed to determine how...
متن کاملAutomatic segmentation of myocardium at risk from contrast enhanced SSFP CMR: validation against expert readers and SPECT
BACKGROUND Efficacy of reperfusion therapy can be assessed as myocardial salvage index (MSI) by determining the size of myocardium at risk (MaR) and myocardial infarction (MI), (MSI = 1-MI/MaR). Cardiovascular magnetic resonance (CMR) can be used to assess MI by late gadolinium enhancement (LGE) and MaR by either T2-weighted imaging or contrast enhanced SSFP (CE-SSFP). Automatic segmentation al...
متن کاملExtent of Myocardium at Risk for Left Anterior Descending Artery, Right Coronary Artery, and Left Circumflex Artery Occlusion Depicted by Contrast-Enhanced Steady State Free Precession and T2-Weighted Short Tau Inversion Recovery Magnetic Resonance Imaging.
BACKGROUND Contrast-enhanced steady state free precession (CE-SSFP) and T2-weighted short tau inversion recovery (T2-STIR) have been clinically validated to estimate myocardium at risk (MaR) by cardiovascular magnetic resonance while using myocardial perfusion single-photon emission computed tomography as reference standard. Myocardial perfusion single-photon emission computed tomography has be...
متن کاملSemi-automatic segmentation of myocardium at risk from contrast enhanced SSFP images - validation against manual delineation and SPECT
Background The development of treatments to limit myocardial injury in patients with acute STEMI is dependent on methods that accurately determine the amount of mycoardium at risk (MaR). Both T2-weighted imaging and contrast enhanced SSFP (CE-SSFP) have been validated against SPECT and can determine the MaR by CMR one week after an infarct. CE-SSFP has recently been used in two multi-center stu...
متن کاملDiagnostic Performance and Safety of Positron Emission Tomography Using 18F-Fluciclovine in Patients with Clinically Suspected High- or Low-grade Gliomas: A Multicenter Phase IIb Trial
Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET...
متن کامل